Nephrology has evolved from one-size-all treatments to a rich pipeline targeting the many diverse causes of Chronic Kidney Disease (CKD). Current nephrology dynamics the REACH team is tracking include:
- Nephrology conditions with high unmet need for FDA approved treatments (e.g., Membranous Nephropathy, FSGS, C3G and Alport Syndrome)
- ACE/ARBs will continue to be the foundation of treatment, and new therapies will be utilized as add-ons to RAS blockade
- New therapies receiving accelerated approval based on proteinuria reduction, however demonstrating improved kidney function over a longer time period, has been a challenging bar to clear (e.g., Travere’s sparsentan in IgAN and FSGS)
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